Oxford Echoes   adventures of a physician-engineer

“Modified Hough Transform for Left Ventricle Myocardium Segmentation in 3-D Echocardiogram Images”

This was the first conference paper to come from my DPhil work in the Oxford Biomedical Image Analysis Laboratory. It describes an extension of the traditional Hough transform to find the left ventricle heart muscle in 3-d ultrasound images. The paper is available here and was given as a poster presentation at the 2012 International Symposium on Biomedical Imaging (ISBI). It was also presented as an abstract at the 2012 NIH-Oxford-Cambridge Colloquium.

JE McManigle, RV Stebbing, JA Noble. Modified Hough Transform for Left Ventricle Myocardium Segmentation in 3-D Echocardiogram Images, in Proceedings of International Symposium on Biomedical Imaging, 2-5 May 2012, Barcelona. IEEE.

Also presented at ISBI 2012 were:

RV Stebbing, JE McManigle, JA Noble. Interpreting Edge Information for Improved Endocardium Delineation in Echocardiograms, in Proceedings of International Symposium on Biomedical Imaging, 2-5 May 2012, Barcelona. IEEE.

“Inter-Modality Registration to Guide Cardiac Procedures”

This poster served as an outline of my planned DPhil project in my first year. It describes the rationale of using offline multimodality registration to power near-real-time applications in cardiac procedures and a few of the steps towards that goal.

This poster was presented at the 2011 NIH-Oxford-Cambridge Colloquium as well as at the International Computer Vision Summer School (ICVSS) 2011.

“NeuroChip Project: In Pursuit of Nanobiosensors”

This poster is the result of my work in Paul Weiss and Anne Andrews’s lab at Penn State over the summer of 2007. It describes the results of efforts to functionalize self-assembled monolayers with neurotransmitters. This poster was designed to be graphics-intensive, for attended presentation.

This poster was presented at the Penn State Physics REU Poster Presentation 2007, and the results were eventually part of a paper in Chemical Communications:

MJ Shuster, A Vaish, HH Cao, AI Guttentag, JE McManigle, AL Gibb, MM Martinez, RM Nezarati, JM Hinds, W-S Liao, PS Weiss, AM Andrews. Patterning small-molecule biocapture surfaces: microcontact insertion printing vs. photolithography. Chem. Commun., 2011, 47, 10641-10643

Note: The data as presented on the poster has not been peer-reviewed; all conclusions are preliminary.

“Granulocyte Chemotaxis in Familial Mediterranean Patients Undergoing Structured Treatment Interruption of Colchicine”

This poster is the result of my work in the Genetics and Genomics Branch of the National Institute of Arthritis, Musculoskeletal, and Skin Diseases at the NIH over the summer of 2006. It describes the results of an experiment in which the chemotaxis, or movement, of a certain type of white blood cell (granulocyte) was measured in FMF patients who interrupted their daily colchicine treatment.

This poster was presented at NIH Summer Poster Day 2006, and the project was later presented at the Fifth International Congress on FMF and Systemic Autoinflammatory Diseases in Rome, 2008 (abstract):

NT Colburn, JE McManigle, P Singal, J Balow Jr, D Mogul, K Zaal, HW Sun, B Barham, JJ Chae, D Kastner. Dissecting Inflammatory and Chemotactic Pathways in Familial Mediterrean Fever [abstract]. ISSAID Conf; 2008; Rome. p 10, abstract 199

And subsequently presented at the 2009 ACR/ARHP Meeting in Philadelphia:

NT Colburn, JJ Chae, K Zaal, J Balow Jr, JE McManigle, I Aksentijevich, HW Sun; Dysfunctional Chemotaxis in Familial Mediterranean Fever [abstract]. Arthritis Rheum 2009;60 Suppl 10 :1481

Note: The data as presented on the poster has not been peer-reviewed; all conclusions are preliminary.

“Using Immunocytochemistry to Study the Effect of Estrogen on Amyloid Protein in Brain Cells”

This poster is the result of my work at the Uniformed Services University of the Health Sciences over the summer of 2003. It describes the results of a preliminary investigation into the role of estrogen in the formation of amyloid bundles, a characteristic feature of Alzheimer’s Disease, in a mouse model.

This poster was presented at various venues, and the project was named a Semifinalist in the Intel Science Talent Search 2004.

Note: The data in this poster has not been peer-reviewed; all conclusions are preliminary.

“Environmental Physiology and Wilderness First Aid”

This presentation was a project for an undergraduate introductory meteorology class. It goes over a few of the basic interactions between environmental physics and physiology that result in illness and injury in wilderness settings.

“Synapse Form and Function”

This presentation was designed to be a basic introduction to synaptic physiology for chemistry students with limited biology training. It is illustration-heavy and relies on narration to fill in the gaps.

“What is Cardiac Arrest?”

This poster was created for Penn State BioDays 2006, a family-oriented educational event.  It was presented in the “Listen to Your Heart” room, and designed to give people a perspective on the causes, progression, and treatment of cardiac arrest, as well as the steps people can take to prevent and respond to heart problems.

“What Happens in a Heartbeat?”

This poster was also created for Penn State BioDays 2006. It describes the basic workings of the human heart, with emphasis on the electrical system. The function of the four chambers of the heart is described, and a brief (somewhat simplified) interpretation of the electrocardiograph of a normal sinus rhythm (regular heartbeat) is given.